Statistical Meta-Analysis

Automated pooled results for Project: axl-meta-1 / Version: v1

Analysis: Event-Free Survival (EFS/PFS)
Pooled analysis of Hazard Ratios for disease progression or death across 4 studies.
Pooled Result
Pooled Hazard Ratio (HR)

0.60

95% CI: 0.42 to 0.85

Heterogeneity (I²): 0%

Study (NCT ID) Hazard Ratio (95% CI)
NCT02998528
0.63 (0.43-0.91)
NCT03425643
0.59 (0.48-0.72)
NCT03302234
1.06 (0.86-1.30)
NCT04025879
0.58 (0.43-0.78)
Pooled Result
0.60 (0.42-0.85)
0.5
1
Favors Intervention | Favors Control
Analysis: Overall Survival (OS)
Pooled analysis of Hazard Ratios for death from any cause across 3 studies.
Pooled Result
Pooled Hazard Ratio (HR)

0.88

95% CI: 0.07 to 11.61

Heterogeneity (I²): 80.8%

Study (NCT ID) Hazard Ratio (95% CI)
NCT02998528
0.57 (0.30-1.07)
NCT03425643
0.72 (0.56-0.93)
NCT03302234
1.08 (0.85-1.37)
Pooled Result
0.88 (0.07-11.61)
0.25
0.5
1
2
4
Favors Intervention | Favors Control
Analyses: pCR & MPR
Analysis of pathological response outcomes.

pCR Data Availability

  • NCT02998528: Provided raw data (43/179 vs 4/179) - Usable
  • NCT03425643: Only provided a Risk Difference - Raw data missing
  • NCT04025879: Only provided an Odds Ratio - Raw data missing

MPR Data Availability

  • NCT02998528: Provided raw data (66/179 vs 16/179) - Usable
  • NCT03425643: Only provided a Risk Difference - Raw data missing
  • NCT04025879: Only provided an Odds Ratio - Raw data missing
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